粉体物性測定のソリューションカンパニー

1. 吸入製剤等の粒子間付着力を重要視する製剤での評価
2. 薬物等の付着性の高い粉体の物性評価　（凝集による不均一の防止）
3. 製剤化する際の薬物の結晶多形の選択　（後工程での付着トラブル防止）
4. 打錠時の杵表面へのスティッキング性の評価
5. 錠剤の硬度予測、固まりやすさなどの物理的性質の予測

等の予測・トラブルシューティングが可能です。

• Y. Shimada, Y. Yonezawa, H. Sunada, Measurement and Evaluation of the Adhesive Force between Particles by the Direct Separation Method, Journal of Pharmaceutical Sciences．92 (3), 560－568 (2003)（英語）
  （内容）　医薬品原料における粒子間付着力測定の測定例と測定方法を解説
• Y. Shimada, M. Sunada, M. Mizuno, Y. Yonezawa, H. Sunada, K. Takebayasi, M. Yokosuka and H. Kimura, Measurement of the Adhesive Force of Fine Particles on Tablet Surfaces and Method of Their Removal, Drug Dev. Ind. Pharm., 26,149-158 (2000)（英語）
  （内容）　錠剤の表面に付着した汚染粉体の付着力測定とその除去方法について解説
• Yasuhiro Shimada, Yorinobu Yonezawa, Hisakazu Sunada et al, The Development of an Apparatus for Measuring the Adhesive Force between Fine Particles、 J. Soc. Powder Technol. Japan, 37, 658-664 (2000)（日本語）
  （内容）　粒子間付着力測定装置の開発と粒子間付着力の測定法
• Yasuhiro Shimada, Tatsuya Ito, Yorinobu Yonezawa, Hisakazu Sunada et al, Measurements of the Adhesive Force of Contaminative Particles on the Capsule Surface and Method of Their Removal, J. Pharm. Sci. & Technol. Japan, 60(1), 35-42(2000)（日本語）
  （内容）　カプセルの表面に付着した汚染粉体の付着力測定と除去方法について解説
• Y. Shimada, Y. Yonezawa, H. Sunada, Measurement of the Adhesive Force between Fine Particles and Application to Drug Development and Manufacturing Process, PHARM TECH JAPAN, 18(12), 2137-2145(2002)（日本語）
  （内容）　医薬品製造における付着力測定の応用
• Y. Shimada, Y. Yonezawa, H.Sunada, Development of an Apparatus for Measuring Adhesive Force Between Fine Particles, KONA, 20, 223-230(2002)（英語）
  （内容）微小粒子間付着力測定装置の開発
• Y. Shimada, Y. Yonezawa, H. Sunada、 Evaluation and Control of the Adhesive Force between Fine Particles by Surface Modification Method、J. Soc. Powder Technol. Japan, 40(5), 344-338(2003)（日本語）
  （内容）表面改質法による粒子間付着力の制御とその測定方法
• Miho Kimura, Yasuhiro Shimada, Takao Ohshima, Daichi Shibata, Naoto Hattori, Yorinobu Yonezawa, Hisakazu Sunada, The Evaluation of Powder Cellulose as a Pharmaceutical Excipient, J. Pharm. Sci. & Technol., Japan, 62(4), 113-123(2002)（日本語）
  （内容）　粉末セルロースの医薬品賦形剤としての評価
• D. Shibata, Y. Shimada, Y. Yonezawa, H. Sunada, Application and Evaluation of Sucrose Fatty Acid Ester as Lubricants in the Production of Pharmaceuticals, J. Pharm. Sci. & Technol., Japan, 62(4), 133-145(2002)（日本語）
  （内容）　ショ糖脂肪酸エステルの打錠用滑沢剤としての評価

• Y. Shimada et al.” Measurement of the Adhesive Force of Contaminative Particles on the Capsule Surface and Method of Their Removal.” World Congress of Pharmacy and Pharmaceutical Sciences 2000 60th Congress of FIP (Austria), August 2000
• Y. Shimada et al.” The Development of an Apparatus for Measuring the Adhesive Force between Fine Particles”, First Asian Particle Technology Symposium, (Thailand), December 2000
• Y. Shimada et al.” The Direct Measurement of the Adhesion Force Between Fine Particles.” World Congress of Pharmacy and Pharmaceutical Sciences 2001 61th Congress of FIP (Singapore), August 2001
• Y. Shimada et al.” Measurement of the Adhesive Force between fine particles and effect of physical factors of fine particle to the adhesive force.” the 4th World Congress on Particle Technology　（Australia）, July　2002
• Y. Shimada et al.” The Evaluation of Powdered Cellulose as A Pharmaceutical Excipient”, World Congress of Pharmacy and Pharmaceutical Sciences 2002 62th Congress of FIP (France), August 2002
• Y. Shimada et al.　”Measurement　and Evaluation of the Adhesive Force between Particles by the Direct Separation Method”, World Congress of Pharmacy and Pharmaceutical Sciences 2003 63th Congress of FIP (Australia) September, 2003

• 「The　Industrial　Pharmacy　Poster　Prize　2000」, World Congress of Pharmacy and Pharmaceutical Sciences 2000 60th Congress of FIP（Austria） Y. Shimada, Y. Yonezawa, H. Sunada, M. Yokosuka, K. Takebayasi, ”Measurement of the Adhesive Force of Fine Particles on Tablet Surfaces and Method of Their Removal.”
• 「Postdoctoral Presentation　Award」, The Pharmaceutical Society of Japan、28th Seminar Meeting, July 14, 2003 Y. Shimada, ”Measurement of the Adhesive Force between Fine Particles and Application to Drug Development and Manufacturing Process”